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3-phenylpropionate degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
3-hydroxybenzoate + NADPH + O2 <=> 2,5-Dihydroxybenzoate + NADP+ + H2O 1.14.13.24 3-hydroxybenzoate 6-monooxygenase

3-fumarylpyruvate + H2O <=> H+ + fumarate + pyruvate 3.7.1
3.7.1.20 3-fumarylpyruvate hydrolase
3.7.1.5 acylpyruvate hydrolase
4.1.1.112 oxaloacetate decarboxylase




(4S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O 4.2.1.80 2-oxopent-4-enoate hydratase

3-Phenylpropionic_acid + ATP + CoA <=> phenylpropionyl-CoA + AMP + diphosphate 6.2.1.B13

3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ <=> H+ + 3-(2,3-dihydroxyphenyl)propanoate + NADH 1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase

3-Phenylpropionic_acid + NADH + O2 + H+ <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ 1.14.12.19 3-phenylpropanoate dioxygenase

3-hydroxybenzoyl-CoA + H2O <=> 3-hydroxybenzoate + CoA + H+ 3.1.2
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase



4-hydroxy-2-oxopentanoate <=> pyruvate + acetaldehyde 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase




maleylpyruvate <=> 3-fumarylpyruvate 5.2.1.2 maleylacetoacetate isomerase
5.2.1.4 maleylpyruvate isomerase


acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)




2,5-Dihydroxybenzoate + O2 <=> maleylpyruvate + H+ 1.13.11.4 gentisate 1,2-dioxygenase
1.13.11.86 5-aminosalicylate 1,2-dioxygenase


benzoyl-CoA + O2 + NADPH + H+ <=> 3-hydroxybenzoyl-CoA + H2O + NADP+ 1.14.13.58 benzoyl-CoA 3-monooxygenase

H+ + 3-(3-hydroxyphenyl)propanoate + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+ 1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase

3-(2,3-dihydroxyphenyl)propanoate + O2 <=> H+ + (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase

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